Aggregation of amphiphiles through the action of hydrophobic interactions isa common feature in soft condensed matter systems and is of particularimportance in the context of biophysics as it underlies both the generation offunctional biological machinery as well as the formation of pathologicalmisassembled states of proteins. Here we explore the aggregation behaviour ofamphiphilic polymers using lattice Monte-Carlo calculations and show that thedistribution of hydrophobic residues within the polymer sequence determines thefacility with which dry/wet interfaces can be created and that such interfacesdrive the aggregation process.
展开▼
